期刊文献+

雄激素对卵泡发育影响的双重性 被引量:10

The dualism effect of androgen on follicular development
下载PDF
导出
摘要 Follicular development is under the strict control of endocrine,paracrine and autocrine mechanism,among which androgen may have double impact on follicular development.Moderate androgen could contribute to facilitating the initiation of follicles from reserve to growth pool and ongoing follicular development.Androgen had been used to improve ovarian response and enhance the efficiency of ovulation introduction.On the other hand,hyperandrogenism in PCOS may inhibit selective follicle growth,lead to follicular arrest,and finally anovulation. Follicular development is under the strict control of endocrine, paracrine and autocrine mechanism, among which androgen may have double impact on follicular development. Moderate androgen could contribute to facilitating the initiation of follicles from reserve to growth pool and ongoing follicular development. Androgen had been used to improve ovarian response and enhance the efficiency of ovulation introduction. On the other hand, hyperandrogenism in PCOS may inhibit selective follicle growth, lead to follicular arrest, and finally anovulation.
出处 《生殖医学杂志》 CAS 2008年第6期423-424,共2页 Journal of Reproductive Medicine
关键词 雄激素 卵泡募集 卵泡生长发育 卵泡发育阻滞 多囊卵巢综合征 Androgens Follicular recruitment Folliculogenesis Follicular arrest Polycystic ovary syndrome
  • 相关文献

参考文献10

  • 1Rice S, Ojha K, Whitehead S, et al. Stage-specific expres sion of androgen receptor, follicle-stimulating hormone receptor, and anti-Mullerian hormone type Ⅱ receptor in single, isolated, human preantral follicles: relevance to polyeystic ovaries[J]. J Clin Endocrinol Metab, 2007, 92 (3): 1034-1040.
  • 2Weil SJ, Vendola K, Zhou J, et al. Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations [J]. J Clin Endocrinol Metab, 1998, 83(7) :2479-2485.
  • 3Takayama K, Fukaya T, Sasano H, et al. Immunohistochemieal study of steroidogenesis and cell proliferation in polycystic ovarian syndrome[J]. Hum Reprod,1996, 11(7) :1387-1392.
  • 4Kimura S, Matsumoto T, Matsuyama R, et al. Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure[J]. Trends Endocrinol Metab, 2007, 18(5):183-189.
  • 5Casson PR, Lindsay MS, Pisarska MD, et al. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series[J]. Hum Reprod, 2000, 15 (10) :2129-2132.
  • 6Barad DH, Gleicher N. Increased oocyte production after treatment with dehydroepiandrosterone [J]. Fertil Steril, 2005, 84(3):756.
  • 7Garcia-Velasco JA, Moreno L, Pacheco A, et al. The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study[J]. Fertil Steril, 2005, 84(1):82-87.
  • 8Laven JS, Mulders AG, Visser JA, et al. Anti-Mullerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age[J]. J Clin Endocrinol Metab, 2004, 89(1):318 323.
  • 9Willis DS, Watson H, Mason HD, et al. Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mecha nism of anovulation[J]. J Clin Endocrinol Metab, 1998, 83 (11) :3984-3991.
  • 10曾海涛,梁晓燕,姚书忠,沈宏伟,焦泽旭,舒益民,庄广伦.多囊卵巢综合征卵泡颗粒细胞提前对黄体生成素反应[J].中国病理生理杂志,2007,23(2):373-375. 被引量:12

二级参考文献10

  • 1李忠香,王自能.生育年龄妇女早期卵泡细胞凋亡和Bcl-2/BAX蛋白表达[J].中国病理生理杂志,2004,20(10):1908-1911. 被引量:6
  • 2Rogerio AL.What are the key features of importance in polycystic ovary syndrome?[J].Fertil Steril,2003,80(2):259 -261.
  • 3Jonard S,Dewailly D.The follicular excess in polycystic ovaries,due to intra-ovarian hyperandrogenism,may be the main culprit for the follicular arrest[J].Human Reproducton Update,2004,10(2):107-117.
  • 4Tajima K,Orisaka M,Hosokawa K,et al.Effects of ovarian theca cells on apoptosis and proliferation of granulose cell:changes during bovine follicular maturation[J].Biol Reprod,2002,66(6):1635-1639.
  • 5LaPolt PS,Oikawa M,Jia XC,et al.Gonadotropin -induced up-and down-regulation of rat ovarian LH receptor message levels during follicular growth,ovulation and luteinization[J].Endocrinology,1990,126(6):3277-3279.
  • 6Hillier SG.Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis[J].Hum Reprod,1994,9(2):188-191.
  • 7McNatty KP,Smith DM,Makris A,et al.The microenvironment of the human antral follicle:interrelation among the steroid levels in antral fluid,the population of granulose cells,and the status of the oocyte in vivo and in vitro[J].J Clin Endocrinol Metab,1979,49(6):851 -860.
  • 8Peluso JJ.Progesterone as a regulator of granulosa cell viability[J].J Steroid Biochem Mol Biol,2003,85(2-5):167-173.
  • 9Coffler MS,Patel K,Dahan MH,et al.Enhanced granulosa cell responsiveness to follicle-stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone[J].J Clin Endocrinol Metab,2003,88(12):5624-5631.
  • 10Amsterdam A,Koch Y,Lieberman ME,et al.Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat[J].J Cell Biol,1975,67(3):894 -900.

共引文献11

同被引文献164

引证文献10

二级引证文献93

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部