3[3]Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: a Laboratory Manu,2nd Edition, CSHL Press,New york, 1989,35 ～ 38
4[5]Smith BF, Baker H J, Curiel DT, et al . Humoral and cellular immune responses of dogs immunized with a nucleic acid vaccinc encoding human carcinoembryonic antigen. Gene Ther, 1998, 5(7) :865 ～868
5[6]Conry RM, LoBuglio AF, Loechel P, et al . A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumoractivity.Gene Ther, 1995,2( 1 ): 59 ～ 65
6[7]Song K, Chang Y, Prud' homme GL. Regulation of T-helper-1versus T-helper-2 activity and enhanccment of tumor immunity by combined DNA - based vaccination and nonviral cytokine gene transfer. Gene Ther,2000,7(6) :481 ～ 492
7[8]Song K, Chang Y, Prud' homme GL. IL-12 plasmid - enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune - gene knockout mice. Gene Ther, 2000, 7 (18):1527 ～ 1535
8[9]Xiang R, Primus RJ, Ruehlmann JM, et al . A dual-function DNA vaccine encoding carcinoembryonic antigen and CD40 ligand trimer induces T cell- mediated carcinoembryonic antigentransgenic mice. J Immunol,2001,167(8) :4560 ～ 4565
9[11]Galvin TA , Muller J, Khan AS. Effect of different promoters on immune responses elicited by HIV- 1 gag/env multigenic DNA vaccine in Macaca mulatta and Macaca nemestrina. Vaccine,2000,18(23) :2566 ～ 2583
10[12]Danko I,Fritz JD,Jiao S, et al .Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Ther, 1994, 1(2):114～ 121
