儿童手足口病502例临床分型探讨

Clinical phasing of 502 patients with hand-foot-mouth disease

目的探讨手足口病临床分型特点。方法回顾性分析502例儿童手足口病的临床分型特点。结果轻型和重型病例在年龄、性别和皮疹的分布上无明显差异性。重型病例中发热持续>72h占54例(55.67%)、肢体抖动占69例(71.13%)、膝反射亢进40例(41.24%)、呕吐17例(17.53%)、白细胞>15×109/L占21例(21.65%)、血糖升高>9mmol/L占19例(19.59%),均明显高于轻型组(P<0.05)。而心功酶增高率无明显差别(P=0.27)。结论肢体抖动、膝反射亢进及呕吐对诊断重型病例较具临床特征性,而心功酶升高与否对于分型无指导意义。

Objective To analyze clinical phasing features of hand-foot- mouth disease patients. Methods The clinical phasing features and the clinical manifestation of 502 children with hand-food-mouth disease were reviewed from April to July, 2008. Results There no significant differences in mild and serious cases in the ditribution of age, sex and in skin rash. In the serious cases 54 cases （55.67%） had fever lasted over 72 hours; body the body vibration occurred to 69 cases （71.13%）, knee reflex hyperfunction occurred to 40 cases （41.24%）, vomiting 17 cases（17.53%）. The count of WBC was over 15×10^9/L in 21 cases （21.65%） Blood sugar rised in 19 cases （19.59%）. No obvious difference in the increase of level of cardiac muscle enzymewas observed in the mild and serious cases. Conclusion The signs of body vibration, knee reflex hyperfunction and vomiting is of clinical value for diagnosis of serious cases.