MAPK级联途径调控植物细胞胞质分裂

MAPK Signal Pathway Controls Plant Cytokinesis

胞质分裂(cytokinesis)是细胞分裂的最后关键一步,产生2个含有完整的遗传物质和胞质细胞器的子细胞.植物胞质分裂包括细胞板的形成,这一过程是在成膜体的牵引下由一些植物特有的步骤完成的.促分裂原活化蛋白激酶(MAPK)级联途径在真核生物中是高度保守的,由MAPKs,MAPKKs,MAPKKKs组成,通过MAPKKK→MAPKK→MAPK的逐级磷酸化传递细胞信号.近来的研究表明,NACK-MAPKKK→MAPKK→MAPK→MAP65构成的信号途径调控植物细胞的胞质分裂.本文就这一信号途径,总结了植物胞质分裂机制的研究进展,并对其中的问题进行了讨论与展望.

Cytokinesis is the final critical step of cell division to generates two daughter cells that contain a full complement of genomic components and cytoplasmic organelles. In plants, cytokinesis involves the formation of a cell plate, which involves many specific steps and facilitates by phragmoplasts to be accomplished. The mitogen-activated protein kinase （MAPK） cascade is composed of mitogen-activated protein kinascs （MAPKs）, mitogen-activated protein kinase kinases （MAPKKs） and mitogen-activated protein kinase kinase kinases （MAPKKKs）, which is highly conserved in eukaryotes. The intracellular signals were relayed and amplified through sequential phosphorylations of MAPKKK→MAPKK→MAPK. Recent researches have shown that the NACK-[d2] MAPKKK→MAPKK→MAPK→MAP65 signaling pathway was involved in the regulation of cytokinesis in plant cells. In this review, we will illustrate how these recent progresses contribute to understanding the mechanism of plant cytokinesis, and discuss the problems and perspectives in this signaling pathway.