基于中药免疫组学对中药方剂免疫调节作用的评估

Evaluation of immune regulation effects of Chinese medicinal formulae based on immunomics of traditional Chinese medicine

目的:探讨和建立对中药复方免疫调节作用的评估方法。方法:根据单味中药免疫效应评估数学模型计算出中药复方每味中药有免疫效应的概率和中药复方有免疫效应的概率;由CNK I文献数据库中调出实验证实具有免疫调节作用的中药复方,根据中药文献学原理验证评估结果。结果:共查及83篇文献符合要求,共计60个方剂,其中有53个中药方剂计算判别有免疫效应,符合率为88%(53/60);有2篇以上文献支持有免疫调节作用的中药复方有免疫调节作用的判别概率平均为0.89±0.03,随机中药组有免疫调节作用的判别概率平均为0.60±0.29,两者有统计学显著差异(P<0.05)。结论:初步证明本研究提出的中药复方免疫调节作用的评估方法对阐述中药方剂的免疫调节效应具有一定的指导意义。

Objective： To investigate the possibility of evaluation the Chinese medicinal formulae with immune regulation effects according to the immunomics of traditional chinese medicine. Method： The possibility of Chinese medicinal formulae with immune regulation effects was obtained from the discriminant equation of the Chinese medicine with immune regulation effects. The original articles about the Chinese medicinal formulae with immune regulation effects were found since 1980 in CNKI. Using literatures determinate immune effects. Result： There were 53 kinds, that with calculated determination, from total 60 Chinese medicinal formulae with literatures determinate on immune regulation effects. The coincidence was 88% （53/60）. The discriminant score was 0. 89 ± 0. 03 in group one （ there were two or more than two articles have been published to support the medicine＇s immune effects and the articles were finished by different unites independendy） and was 0. 60±0. 29 in group of random Chinese medicinal formulae. There was a significant deviation （P 〈 0. 05）. Conclusion： It was proved preliminarily that the principle of calculation presented in this paper is valuable for the immunomics of traditional Chinese medicine.