507例体检者人群乙型肝炎病毒感染状况调查

The Survey of Infections Status of Hepatitis B during Physical Examination among 507 People

调查本院体检者乙型肝炎病毒（HBV）感染状况。采用微粒子酶联免疫吸附法和实时荧光定量聚合酶链反应（FQ—PCR）分别测定507例体检者血清中乙肝五项和HBV DNA载量。体检者按30～40岁、41-50岁、51～60岁分成三个年龄组，对结果进行年龄组间比较。507例受检人员的表面抗原（HBsAg）阳性率为17．75％，其中男性为19．84％，女性为11．63％，男性阳性率显著高于女性（P〈0．01）。表面抗原的阳性率随年龄的增加而降低，三个年龄段表面抗原的阳性率分别为20．51％、17．43％和16．11％。检测结果表明HBeAg和HBV DNA载量有较好的一致性，HBsAg为阴性的417例中检出HBV DNA载量大于500的1例。本次调查该年龄段人群乙型肝炎病毒感染水平较高，尤其是30多岁的男性更应该增强自我防护意识，定期进行健康检查，以便早发现早治疗。

To investigate the Hepatitis B infection status during physical examination, the serum levels of HBsAg, Anti-HBs, HBeAg, Anti-HBe, Anti-HBc and HBV DNA capacities in 507 people were detected by ELISA and FQ-PCR. The subjects were divided into three groups according to the age from 30 to 40, 41 to 50, and 51 to 60 years old. The results showed that the HBsAg positive rate in 507 people was 17.75%. The positive rate in male was significant higher than that of in female（P 〈 0.01 ） , it was19.84% and 11.63% respectively. The positive rate of HBsAg was decreased gradually as the increase of age. The positive rates of HBsAg were 20.51% , 17.43% and 16.11% in three age groups respectively. The HBeAg quantity and HBV DNA capacities showed a good correlation. There was only one sample showed a higher HBV DNA capacity in 417 people with HBsAg negative results. The results indicated that the people grouping this survey have high infection rate of HBV virus. The people over 30 years old male should take the physical examination regularly, in order to find the illness and treat it in early stage.