肿瘤标志物mesothelin在胰腺癌组织的表达及其临床意义

Expression and Clinical Significance of Mesothelin in Pancreatic Carcinoma

研究胰腺癌组织mesothelin的表达及其与临床肿瘤指标的关系。收集43例手术切除的胰腺癌及39例癌旁胰腺组织石蜡标本,利用EnV ision免疫组化法分别检测癌组织和癌旁胰腺组织mesothelin的表达情况。结果显示,43例胰腺癌组织中mesothelin阳性表达32例(74.4%),39例癌旁胰腺组织中无阳性表达病例;mesothelin阳性率与肿瘤分化程度有关(P<0.005),与肿瘤的大小、淋巴及远处转移无关(P>0.05)。结论:mesothelin在胰腺癌组织中有较高的阳性表达率,检测其表达有助于胰腺癌的诊断,并可作为判断胰腺癌恶性程度的重要指标。

To investigate the expression of mesothelin in human pancreatic carcinoma and to explore its relationship to differentiation degree, the size, invasion and metastasis of human pancreatic carcinoma. The expression of mesothelin in 43 pancreatic carcinoma samples and in 39 adjacent normal pancreatic tissues was detected by using immunohistochemical EnVision method. The results showed that the positive expression of mesothelin in 43 pancreatic carcinoma tissues was 32 cases （74.4%） and there was no positive expression of mesothelin in 39 adjacent normal pancreas tissues. The expression of mesothelin was markedly correlated to the differentiation degree ofpancreatic carcinoma （P 〈 0.005 ）, but had no relationship with the tumor size, invasion and metastasis of pancreatic carcinoma （ P 〉 0.05 ）. The detection of expression of mesothelin is helpful in the diagnosis of pancreatic carcinoma, and it might be also regards as an important parameter for determining tumor malignant degree.