2003～2007年碳青霉烯类抗生素用药密度对细菌耐药性影响结果分析

Analysis of the Effect of the Use Density of Carbapenems on Drug-resistance of Bacteria from 2003 to 2007

目的:探讨碳青霉烯类抗生素用药密度变化对细菌耐药性所产生的影响。方法:对某院ICU病房碳青霉烯类抗生素的用药密度、相关致病菌的种类构成和耐药监测结果进行连续5年的分布汇总,分析对应时段的量变数据。结果:非发酵革兰阴性菌(NFGNB)对碳青霉烯类易产生耐药,且耐药率随用药密度的升降而波动。肠杆菌属细菌对碳青霉烯类的耐药率低,受用药密度的影响较小。结论:碳青霉烯类用药密度与NFGNB耐药率的变化呈正相关。合理控制用药密度可使细菌耐药率减缓或下降。

Objective ： To investigate the effect of the fluctuation of use density of carbapenems on the drug-resistance of bacteria. Method： The data including the use density of carbapenems, kinds and results of drug-resistance of correlative pathogenic bacteria were collected and statistically analyzed from the ICU ward of our hospital during 2003-2007. Result： NFGNB were prone to produce the drug resistance to carbapenems and the resistant rate fluctuated as the antibiotics use density fluctuated. Conclusion： The use density of carbapenems has a positive correlation with the changing rate of NFGNB＇s resistant rate. By reasonable control of the use of antibiotics, the dropping of the drug-resistance rates can be expected.