摘要
本文通过分析一般ＱＳＢＲ模型应用的特点、不足和影响有机物生物降解的基本因素，指出ＱＳＢＲ模型应综合反映影响有机物生物降解的四个方面（以氯代芳香化合物为例）：氯代苯系物的摄入、氯代苯系物的诱导作用、毒性物质的形成和基础酶的缺乏。在此基础之上给出了动态ＱＳＢＲ的概念模式及方法学基础。
It is analyzed in this paper that the characteristic and deficiency for the application of general QSBR models and the basic elements influencing the biodegradation of organic chemicals. The QSBR models should reflect the four aspects which influence the biodegradation of organic chemicals(chloroaromatic compounds): uptake of chloroaromatic compounds; chloroaromatic compounds as inducers; formation of toxic products and lack of essential enzymes. The concept mode and methodology basis of dynamic QSBR mode are given in this paper.
基金
国家自然科学基金
