甲基汞对大鼠小脑的脂质过氧化作用

Effect of Methylmercury on the Lipid Peroxidation in the Cerebellum of Rats

研究了氯化甲基汞（ＭｅＨｇＣｌ）经口染毒不同剂量及不同时间对大鼠小脑中脂质过氧化产物（ＬＰＯ）及还原型谷胱甘肽（ＧＳＨ）的影响。小脑中ＬＰＯ的含量随着染毒剂量的增加和染毒时间的延长而升高，且有剂量－效应关系和时间－效应关系；ＧＳＨ含量除２．５ｍｇ／ｋｇ剂量组外，其它各组随着染毒剂量的增加和染毒时间的延长而降低，亦有剂量－效应关系和时间－效应关系。本研究提示：ＭｅＨｇ可诱发大鼠小脑的脂质过氧化作用。

Effects of methylmercury chloride in different doses and periods in lipid peroxidation (LPO) and glutathione(GSH) in the cerebellum of rats were studied respectively.The level of LPO was significantly increased in a doseand timedependent mannerThe content of GSH was significantly reduced in a doseand timeependent fashion except in the 25mg/kg dosed group.The present study indicated that methylmercury could induce lipid peroxidation in the cerebellum of rats.