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TGF-β信号转导通路与肺癌关系的研究现状 被引量：5

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摘要 转化生长因子β(TGF-β)是多效能细胞因子,具有广泛的生物活性。TGF-β被激活后具有生物学活性,与TβRII结合形成二聚体使TβRI磷酸化,随后R-Smads被磷酸化并与Co-Smad形成异源复合物移至核内,调节靶基因的转录。TGF-β信号通路调控着上皮细胞的生长分化,这些细胞由于TGF-β受体表达的下降或缺失、Smad突变导致细胞对TGF-β信号失去反应,从而导致肺部肿瘤的发生。
作者 丁秀娟 潘林娜
机构地区 哈尔滨医科大学附属肿瘤医院腔镜室
出处 《实用肿瘤学杂志》 CAS 2008年第6期562-565,共4页 Practical Oncology Journal
关键词 TGF-Β SMADS 肺癌
分类号 R734.2 [医药卫生—肿瘤]
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参考文献20

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二级参考文献19

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共引文献5

同被引文献47

  • 1彭瑞云,王德文,高亚兵,杨瑞彪,刘萍,王芝萍,李延平,白蕴红,王晓民,熊呈琦,谢国良,徐在海.肥大细胞在放射性肝纤维化中的改变与作用的研究[J].中华放射医学与防护杂志,1994,14(1):29-32. 被引量：8
  • 2杨玲,李连弟,陈育德,Donald Maxwell Parkin.中国肺癌死亡趋势分析及发病、死亡的估计与预测[J].中国肺癌杂志,2005,8(4):274-278. 被引量：168
  • 3杨竹林,黄生福,苗雄鹰,钟德玝,梁珊.胰腺癌组织中CCN家族基因和转化生长因子-β1表达及其临床病理意义[J].中华实验外科杂志,2005,22(10):1276-1276. 被引量：8
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引证文献5

二级引证文献6

实用肿瘤学杂志
2008年 第6期

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