新法合成5-硝基香兰酸

5-nitrovanillic acid:A new synthesis

目的:研究了5-硝基香兰酸的合成方法。方法:以4-甲基愈创木酚为原料,先用乙酸酐将酚羟基保护起来,再通过强氧化剂的氧化作用将甲基氧化为羧基,最后水解得香兰酸,再经硝化制得5-硝基香兰酸。结果:得到亮黄色晶体产物,收率为73%。结论:本法操作简易,原料易得,适合工业生产。

Objective ：To study the new synthesis of 5--nitrovanillic acid. Method：5--Nitrovanillic acid was synthesized from 4--methyl guaiacol,which reacted with acetic anhydride to protect phenol hydroxyl,and then the methyl was oxidated by strong oxidizer to become the carboxyl group,and finally vanillic acid was obtained through hydrolysising the compound, followed by nitration at last. Result： The bright yellow crystal product was obtained and an overall yield of production was 73 %. Conclusion：This method is very easy,basic materials can be easily obtained, suitable to the industry production.