摘要
目的探讨不同产地牡丹皮(安微铜陵产凤丹皮和云南昆明产滇丹皮)提取物的降血脂药理作用研究并评价其对血液流变学指标的影响,对其药效作用进行比较。方法建立大鼠高脂血症动物模型,同时给予丹皮提取物进行灌胃给药28 d,末次给药后取血检测血清中血脂水平和血液流变学指标。结果模型组高脂血症大鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及血液流变学指标全血粘度(ηb)、血浆粘度(ηp)、血小板聚集率(PA)及纤维蛋白原(F ib)较正常组明显升高(P<0.05)。与模型组比较,道地药材凤丹皮提取物组TC,LDL-C,ηb(50 s-1),ηp,PA,F ib明显降低(P<0.05),降低TG但无显著性差异(P>0.05);滇丹皮提取物组LDL-C、F ib明显降低(P<0.05),TC和TG亦有降低趋势,但与其他指标均无显著性差异(P>0.05)。结论不同产地牡丹皮降血脂药效不同,在药材选用上,应结合此特点加以区别和质控。
Objective To study the anti - hyperlipidemia effects of extracts from different species of Cortex Moutan ( mainly derived from P. sufruticosa Anhui and P. delavayi Yunnan) in rats. Methods In this study, the extracts were administered i. g. into fatemulsion - induced hyperlipidemia model rats for 28 days. The serum TC, TG, LDL - C and hemorheology indices were determined 'after the last administration. Results The TG, TC, LDL - C, ηqb, ηp, PA, Fib of the hyperlipidemia rats in the control group were increased significantly (vs. normal, P 〈 0.05). The P. sufruticosa extracts decreased TC, LDL - C,ηb (50s - 1 ) , ηp, PA and Fib significantly ( vs. control, P 〈 0.05 ) ; P. delavayi extracts decreased LDL - C and Fib significantly ( vs. control, P 〈0.05 ), but tended to decrease other indices (c. g. TC and TG) without significant difference (vs. control, P 〉0.05). Conclusion The extracts from different species of Cortex Moutan show different anti - hyperlipidemia effects in rats, which should be taken into account in their application and quality control.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第12期2962-2963,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家中医药管理局重大项目基金资助项目(No.国中医药科2001ZDZX005)
关键词
牡丹皮
降血脂
血液流变学
大鼠
Cortex Moutan
Anti - hyperlipidemia
Hemorheology
Rats