不同产地牡丹皮提取物的降血脂作用研究

Anti-hyperlipidemia Effects of Extracts from Different Species of Cortex Moutan

目的探讨不同产地牡丹皮(安微铜陵产凤丹皮和云南昆明产滇丹皮)提取物的降血脂药理作用研究并评价其对血液流变学指标的影响,对其药效作用进行比较。方法建立大鼠高脂血症动物模型,同时给予丹皮提取物进行灌胃给药28 d,末次给药后取血检测血清中血脂水平和血液流变学指标。结果模型组高脂血症大鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及血液流变学指标全血粘度(ηb)、血浆粘度(ηp)、血小板聚集率(PA)及纤维蛋白原(F ib)较正常组明显升高(P<0.05)。与模型组比较,道地药材凤丹皮提取物组TC,LDL-C,ηb(50 s-1),ηp,PA,F ib明显降低(P<0.05),降低TG但无显著性差异(P>0.05);滇丹皮提取物组LDL-C、F ib明显降低(P<0.05),TC和TG亦有降低趋势,但与其他指标均无显著性差异(P>0.05)。结论不同产地牡丹皮降血脂药效不同,在药材选用上,应结合此特点加以区别和质控。

Objective To study the anti - hyperlipidemia effects of extracts from different species of Cortex Moutan （ mainly derived from P. sufruticosa Anhui and P. delavayi Yunnan） in rats. Methods In this study, the extracts were administered i. g. into fatemulsion - induced hyperlipidemia model rats for 28 days. The serum TC, TG, LDL - C and hemorheology indices were determined ＇after the last administration. Results The TG, TC, LDL - C, ηqb, ηp, PA, Fib of the hyperlipidemia rats in the control group were increased significantly （vs. normal, P 〈 0.05）. The P. sufruticosa extracts decreased TC, LDL - C,ηb （50s - 1 ） , ηp, PA and Fib significantly （ vs. control, P 〈 0.05 ） ; P. delavayi extracts decreased LDL - C and Fib significantly （ vs. control, P 〈0.05 ）, but tended to decrease other indices （c. g. TC and TG） without significant difference （vs. control, P 〉0.05）. Conclusion The extracts from different species of Cortex Moutan show different anti - hyperlipidemia effects in rats, which should be taken into account in their application and quality control.