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维生素D受体基因FokI多态性与2型糖尿病的关系 被引量:11

Association between the VDR Gene Fok I Polymorphism and Type 2 Diabetes
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摘要 探讨湖南地区汉族人群维生素D受体(VDR)基因Fok I位点多态性与2型糖尿病(T2DM)的关系。研究对象为853例,其中T2DM组473例和正常对照组380例。采用聚合酶链反应-限制性片断长度多态(PCR-RFLP)法检测VDR基因Fok I位点基因型。比较两组VDR基因Fok I位点基因型分布和等位基因频率,分析VDR基因Fok I位点多态性与胰岛β细胞功能的关系。T2DM组f等位基因频率高于正常对照组(P<0.05),T2DM组Ff和ff基因型分布频率高于正常对照组(P<0.05)。T2DM组FBG、PBG水平高于正常对照组(P<0.05)。T2DM组ff基因型组的口服葡萄糖耐量后2 h胰岛素低于FF基因型组(P<0.05)。VDR基因Fok I多态性与中国湖南地区汉族人群T2DM发病相关,VDR基因ff基因型和Ff基因型可能是T2DM的发病风险因素。 To study the association between the VDR gene Fok Ⅰ polymorphism and type 2 diabetes853 individuals were examined :473 type 2 diabetic patients and 380 unrelated healthy subjects. The study groups were recruited from Han Chinese in Hunan province. Genotyping for VDR gene Fok Ⅰ polymorphism were performed by RFLPPCR technique. Significantly higher frequency of ff and Ff genotype and f allele was presnet in type 2 diabetic patients than in controls ( P 〈 0.05 ). Higher levels of FBG and PBG in T2DM than controls was observed ( P 〈 0. 05 ). T2DM patients showed lower insulin level at 2h after 75 - g oral glucose than controls ( P 〈 0.05). VDR gene Fok Ⅰ polymorphism was associated with T2DM in Han Chinese Populations of Hunan province, suggesting VDR gene Fok Ⅰ ff genotype and Ff genotype may be a genetic mark for predicting risk of type 2 diabetes.
出处 《南昌大学学报(理科版)》 CAS 北大核心 2008年第5期489-492,共4页 Journal of Nanchang University(Natural Science)
基金 国家自然科学基金资助项目(30670991)
关键词 2型糖尿病 维生素D受体基因 单核苷酸多态性 type 2 diabetes VDR gene single nucleotide polymorphism
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参考文献14

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二级参考文献10

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