脑功能显像剂^(99)Tc^m-Memantine的初步研究

Preliminary Study of ^(99)Tc^m-Memantine as an Brain Functional Imaging Agent

用^(99)Tc^m标记N-[2-(N-(2-巯基乙基))氨基甲酰甲基]-N-(2-巯基乙基)-3,5-二甲基金刚烷胺基乙酰胺(N_2S_2-Memantine),生成了^(99)Tc^m(V)-Memantine。采用纸层析对此标记物进行质控并检测其体外稳定性。结果显示,湿法的标记率>90%,药盒化标记的标记物经乙酸乙酯萃取纯化后,放化纯度>95%,体外稳定性良好,有望成为一种新的脑功能显像剂。

N2S2-Memantine was labeled with 99Tcm using stannous fluoride as reducing agent, and the labeling conditions of 99 Tcm Memantine were optimized, and lyophilized kit of 99Tcm（V）-Memantine was also developed. The labeling efficiency was more than 90% by TLC and the kit radiochemical purity which was after extraction with ethyl acetate, was more than 95% . The stability was good in room temperature. 99Tcm（ V ）-Memantine would be a potential brain imaging agent which would need more research work.