血清抗环瓜氨酸肽抗体在类风湿关节炎诊断中的作用

Application of Anti-cyclic Citrullinated Peptide in Diagnosing Rheumatoid Arthritis

目的探讨抗环瓜氨酸(CCP)抗体在类风湿关节炎(RA)诊断中的作用。方法用ELISA法及速率放射免疫比浊法分别检测RA及非RA患者血清中的抗CCP抗体和RF,比较抗CCP抗体及RF对RA诊断的敏感性、特异性及早期RA诊断预测性方面的差异。结果抗CCP抗体在诊断早期RA中的敏感性为75.0%、RF为53.2%;抗CCP抗体的特异性为92.3%,RF为76.1%。抗CCP抗体在RA中的阳性表达率高于RF(P<0.01);抗CCP抗体和RF在RA中的阳性表达率高于Non-RA(P<0.01)。结论抗CCP抗体在RA有较强敏感性、特异性及早期RA诊断预测性,可作为早期诊断RA的有价值的血清学指标。

Objective To explore the significance of anti-cyclic citntllinated peptide antibody in diagnosing rheumatoid arthritis. Methods Anti-CCP in patients with the chief complaint of joint pain or swelling was measured by ELISA. Results The sensitivity of anti-CCP and RF in diagnosing of RA was 75.0% and 53.2 % respectively The specificity was 92.3 % and 76.1%. The sensitivity and specificity of anti-CCP was significantly higher than that of RF（ P 〈 0.01 ）. Anti-CCP had greater diagnostic value than RF in early diagnosis of RA. Conclusion The anti- CCP presents a good sensitivity and specificity in diagnosis of RA.