前列环素对随意皮瓣血液流变学的影响

Effect of prostacyclin on hemorrheology of random skin flaps

目的：探讨前列环素对随意皮瓣血液流变状态以及成活情况的影响。方法：以ＳＤ大鼠为模型，于其背部设计蒂在尾部长９ｃｍ、宽３ｃｍ的随意皮瓣。术前及术后经尾静脉注射一定量的前列环素，对照组给等量生理盐水，观察术后７ｄ皮瓣的成活面积，并测定了术后不同时刻的血液流变学变化。结果：术后给药组皮瓣的成活面积显著大于对照组。结论：前列环素可以通过降低术后皮瓣的血小板聚集率、血浆纤维蛋白原浓度以及全血还原比粘度，改善皮瓣的微循环状态，从而促使皮瓣成活。

bjective:To explore the effect of prostacyclin on hemorrheology and survival of random skin flaps. Methods:A 9 cm×3 cm sized flap was designed on the back of 96 SD rats. Prostacyclin was injected through caudal vein preoperatively (group 1) and postoperatively (group 2), and saline was injected as a controls (group 3).Results:The survival area of flaps in group 2 was greater than that control group.Conclusions:Prostacyclin can improve the viability of flaps by means of lowing platelet aggregation,blood viscosity and plasma fibrinogen.It should be injected immediately after operation.