宫颈癌及宫颈上皮内瘤变与人乳头瘤病毒感染的相关分析

Clinical analysis of correlation between the HPV-DNA and cervical carcinoma and its precancerous lesions

目的探讨人乳头瘤病毒(HPV-DNA)在慢性宫颈炎、宫颈上皮内瘤变(CIN)及浸润性宫颈癌(ICC)中的表达,以及它们之间的相互关系,通过HPV-DNA的检测尽早筛查出患宫颈上皮内瘤变及浸润性宫颈癌的高危人群,以便采取有效的预防措施。方法对本院2006年7月-2007年7月妇科门诊及住院部筛查出的130例宫颈病变患者均采用PCR-HPV荧光定量检测法检测其宫颈分泌物HPV-DNA感染情况,并通过阴道镜对可疑病灶多点活检。结果130例宫颈病变患者中HPV-DNA阳性者52例(40.0%),阴性者78例(60%);病理活检慢性炎症53例(40.8%),宫颈癌及癌前病变77例(59.2%);HPV阳性患者的宫颈癌及癌前病变率为62.3%(48/77)。结论检测高危HPV-DNA不仅可以发现现行的宫颈疾病的患者,还可以发现存在高危风险的人群,是监测CIN及ICC的一个重要的指标;通过检测高危HPV-DNA,有针对性地进行活组织病理检查,可有效地指导临床,有助于探讨CIN及ICC的发病机制。

Objective To explore the expression of human papillomavirus （HPV） in the cervical carcinoma and its precancerous lesions and to explore the relationship between HPV and the pre - operation diagnosis of CIN and ICC. Methods One hundred and thirty patients with cervical intraepithelial neoplasia diagnosed and treated in our hospital between 2006 -2007 were retrospectively analyzed. Results In 130 patients, there were 52 （40%） cases expressed positive of HPV infection masculine, and 78 （60%） cases expressed negative. According to cervical biopsy, 53 patients （40. 8% ） got chronic cervicitis, 77 patients （59.2%） got cervix malignant disorders. The rate of cervix malignant in patients who has got HPV infection is 62.3% （48/77）. Conclusion It is an important auxiliary way to evaluate the CIN and ICC by detecting the high risk HPV infection. Combination of HPV detection and biopsy is helpful in improving the diagnosis rate and elucidating the pathogenesis of CIN and ICC.