期刊文献+

光线性角化病48例分析 被引量:4

下载PDF
导出
摘要 目的探讨光线性角化病的临床及病理表现。方法总结分析48例光线性角化病的临床及病理资料。结果光线性角化病发生于61-75岁者占66.67%,男女性别比为1∶1.18;发生于面颊部18例(33.34%),其中肥厚型者9例占45.83%,转化为鳞状细胞癌者1例占2.08%。肥厚、萎缩、间变、棘层松解、色素沉着等表现是该病的组织病理学基础。结论光线性角化病好发于老年人,面颊部最多发,以肥厚型常见。组织病理学特点主要为表皮下层不典型角质形成细胞成芽蕾状进入真皮乳头层,可见丝状分裂相,有转化为鳞状细胞癌的风险。
出处 《宁夏医学杂志》 CAS 2008年第12期1181-1182,共2页 Ningxia Medical Journal
  • 相关文献

参考文献2

二级参考文献11

  • 1Stockfleth E,Meyer T,Benninghoff B,et al.A randomized,double-blind,vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses.Arch Dermatol 2002;138:1498-1502.
  • 2Chen K,Yap LM,Marks R,et al.Short-course therapy with imiquimod 5% cream for solar keratoses:a randomized controlled trial.Australas J Dermatol 2003;44:250-255.
  • 3Lebwohl M,Dinehart S,Whiting D,et al.Imiquimod 5% cream for the treatment of actinic keratosis:results from two phase Ⅲ,randomized,double-blind,parallel group,vehicle-controlled trials.J Am Acad Dermatol 2004;50:714-721.
  • 4Szeimies RM,Gerritsen MJ,Gupta G,et al.Imiquimod 5% cream for the treatment of actinic keratosis:results from a phase Ⅲ,randomized,double-blind,vehicle-controlled,clinical trial with histology.J Am Acad Dermatol 2004;51:547-555.
  • 5Korman N,Moy R,Ling M,et al.Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis:results of two phase 3,randomized,double-blind,parallel-group,vehicle-controlled trials.Arch Dermatol 2005;141:467-473.
  • 6Yantsos VA,Conrad N,Zabawski E,et al.Incipient intraepidermal cutaneous squamous cell carcinoma:a proposal for reclassifying and grading solar (actinic) keratoses.Semin Cutan Med Surg 1999;18:3-14.
  • 7Cockerell CJ.Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis").J Am Acad Dermatol 2000;42(1,Pt 2):S11-17.
  • 8Tyring S.Immune response modification:imiquimod.Australas J Dermatol 1998;39(Suppl 1):S11-13.
  • 9Slade HB,Owens ML,Tomai MA,et al.Imiquimod 5% cream (Aldara).Expert Opin Investig Drugs 1998;7:437-449.
  • 10Hemmi H,Kaisho T,Takeuchi O,et al.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.Nat Immunol 2002;3:196-200.

共引文献91

同被引文献14

  • 1Bauer J.,Leinweber B.,Metzler G.,H.P.Soyer,党倩丽.数字皮肤镜图像可帮助皮肤病理医生诊断可疑的皮肤肿瘤[J].世界核心医学期刊文摘(皮肤病学分册),2006(12):5-6. 被引量:1
  • 2Gilbert DJ.Treatment of actinic keratoses with sequential combination of 5-fluorouracil and photodynamic therapy[J].Drugs Dermatol,2005,4 (2):161-163.
  • 3Wollina U,Konrad H,Karamfilov T.Treatment of common warts and actinic keratoses by Er:YAG laser[J].Cutan Laser Ther,2001,3 (2):63-66.
  • 4赵辨.临床皮肤病学[M].南京:江苏科学技术出版社,1988.393.
  • 5Philip EL;David W;Alain S.皮肤肿瘤病理学和遗传学(世界卫生组织肿瘤分类及诊断标准系列)[M]北京:人民卫生出版社,200640-42.
  • 6Reagan-Shaw S,Mukhtar H,Ahmad N. Resvertrao imparts pho-toprotection of normalcells and enhances the efficacy of radiation therapy in cancer cells[J].Photochemistry and Photobiology,2008,(02):415-421.doi:10.1111/j.1751-1097.2007.00279.x.
  • 7Wollina U,Konrad H,Karamfilov T. Treatment of common warts and actinic keratoses by Er:YAG laser[J].Cutan Laser Ther,2001,(02):63-66.
  • 8赵辨.临床皮肤病学[M]南京:江苏科学技术出版社,2001577-578.
  • 9Giuffr G,Barresi V,Catalano A. Actinic keratos is asso-ciated with squamous and basal cell carcinomas:an evaluation of neoplastic progression by a standardzed AGNOR analysis[J].Eur J H istochem,2008,(01):53-60.
  • 10孟如松,赵广.皮肤镜图像分析技术的基础与临床应用[J].临床皮肤科杂志,2008,37(4):264-267. 被引量:19

引证文献4

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部