摘要
目的探讨超声造影结合时间强度曲线定量评价兔肾血流灌注的可行性。方法应用实时超声造影成像技术(contrast tuned imaging,CnTi)与超声造影剂对12只健康家兔两侧肾脏进行超声造影,然后应用时间强度曲线对两侧肾血流灌注情况进行定量分析,得到开始增强时间、达峰值时间、峰值强度、曲线上升斜率、曲线下面积。结果①正常肾血流灌注模式:造影剂团注5-8s后,肾段动脉、叶间动脉呈快速"树枝状"增强,之后肾皮质、肾髓质、肾窦依次增强;肾髓质、肾窦较肾皮质强化慢,廓清次序为肾窦、肾髓质、肾皮质。②双侧肾皮质或髓质超声造影同一定量参数比较差异无统计学意义(P>0.05)。同侧肾皮质的开始增强时间、达峰值时间较髓质早(P<0.05),峰值强度、曲线上升斜率、曲线下面积大于髓质(P<0.05)。结论超声造影时间强度曲线定量参数能反映正常肾血流灌注特征。
Objective To explore the feasibility of contrast-enhanced uhrasound(CEUS)combined with Wash-in/Wash-out time intensity curve in quantitative evaluation of renal perfusion flow in rabbits. Methods Twelve normal rabbits(24 kidneys)underwent CELTS by using contrast tuned imaging technology(CnTi)and SonoVue. Then renal perfusion flow was evaluated with time intensity curve software. The time to enhancement, time to peak intensity, peak signal intensity, ascending slope rate of the curve and area under the curve were determined. Results ①The perfusion mode of normal kidney showed that after a bolus injection of ultrasound contrast media for 5 - 8 s, the blood signals of renal segmental artery, interlobar artery, cortex, medulla and sinus were enhanced by turns. The signals of renal medulla and sinus were enhanced more slowly than that of renal cortex. And the signals of renal sinus, medulla and cortex washed out by turns. ②The time to enhancement, time to peak intensity, peak signal intensity, ascending slope rate of the curve and area under the curve in cortex or medulla had no significant difference between bilateral kidneys, respectively (P 〉 0.05). But in the same kidneys, time to enhancement and time to peak intensity were earlier in renal cortex than in renal medulla( P〈 0.05). The peak signal intensity, ascending slope rate of the curve, and area under the curve were larger in renal cortex than in renal medulla(P 〈 0.05). Conclusion Quantitative parameters of CEUS could reflect the features of renal perfusion flow.
出处
《山西医科大学学报》
CAS
2008年第12期1078-1080,共3页
Journal of Shanxi Medical University
关键词
超声检查
造影剂
肾血流灌注
ultrasonography
contrast media
renal perfusion