摘要
目的:探讨125I粒子治疗肿瘤骨转移的临床疗效。方法:对40例不同肿瘤来源的骨转移患者的52个病灶行125I粒子永久植入治疗,观察骨痛缓解情况以及术后骨转移病灶的影像学变化。结果:125I粒子永久植入治疗骨转移灶的止痛有效率为92.5%,其中显效23例、有效14例、无效3例,总缓解率为92.5%;治疗后疼痛分级较治疗前有明显降低(P<0.05)。术后2个月的影像学检查结果显示,部分缓解病灶为12个、稳定32个、进展8个。所有患者均未出现严重的不良反应。结论:组织间永久植入125I粒子治疗肿瘤转移灶疗效确定,不良反应的发生率较低且严重度较轻,是一种值得推广的治疗方法。
Objective:To evaluate the clinical efficacy of permanent implantation of iodine 125 seeds in the treatment of osseous metastases. Methods:Radioactive iodine 125 seeds were implanted permanently in 52 lesions of forty patients with osseous metastases of different origins. The ostalgia-relieving degree and the imaging alterations of the osseous metastasis lesions were observed. Results: The effective pain-relieving rate was 92.5 % (37/40) caused by permanent implantation of iodine 125 seeds. Of all the patients ,23 patients achieved complete response, 14 patients obtained partial response (PR) , and 3 patients had no change. The total effective rate was 92.5%. The pain grade was decreased significantly after the treatment (P 〈 0.05 ). Imaging examination showed that 12 lesions had partial response, 32 lesions had stable disease, and 8 lesions had progressive disease at 2 months after surgery. All the patients had no serious adverse reactions. Conclusion:Permanent implantation of ^125I seeds has a definite effects on tumor metastasis and caused minimal damage and few complications. It is worthy of popularization in clinic.
出处
《肿瘤》
CAS
CSCD
北大核心
2008年第12期1106-1108,共3页
Tumor