^125I粒子植入治疗骨转移瘤的临床应用

The clinical application of permanent implantation of iodine 125 seeds for osseous metastases

目的:探讨125I粒子治疗肿瘤骨转移的临床疗效。方法:对40例不同肿瘤来源的骨转移患者的52个病灶行125I粒子永久植入治疗,观察骨痛缓解情况以及术后骨转移病灶的影像学变化。结果:125I粒子永久植入治疗骨转移灶的止痛有效率为92.5%,其中显效23例、有效14例、无效3例,总缓解率为92.5%;治疗后疼痛分级较治疗前有明显降低(P<0.05)。术后2个月的影像学检查结果显示,部分缓解病灶为12个、稳定32个、进展8个。所有患者均未出现严重的不良反应。结论:组织间永久植入125I粒子治疗肿瘤转移灶疗效确定,不良反应的发生率较低且严重度较轻,是一种值得推广的治疗方法。

Objective：To evaluate the clinical efficacy of permanent implantation of iodine 125 seeds in the treatment of osseous metastases. Methods：Radioactive iodine 125 seeds were implanted permanently in 52 lesions of forty patients with osseous metastases of different origins. The ostalgia-relieving degree and the imaging alterations of the osseous metastasis lesions were observed. Results： The effective pain-relieving rate was 92.5 % （37/40） caused by permanent implantation of iodine 125 seeds. Of all the patients ,23 patients achieved complete response, 14 patients obtained partial response （PR） , and 3 patients had no change. The total effective rate was 92.5%. The pain grade was decreased significantly after the treatment （P 〈 0.05 ）. Imaging examination showed that 12 lesions had partial response, 32 lesions had stable disease, and 8 lesions had progressive disease at 2 months after surgery. All the patients had no serious adverse reactions. Conclusion：Permanent implantation of ^125I seeds has a definite effects on tumor metastasis and caused minimal damage and few complications. It is worthy of popularization in clinic.