12例骨孤立性浆细胞瘤的临床特点与预后回顾性分析

Retrospective analysis of the relation between the clinical features and prognosis of 12 solitary plasmacytoma of bone patients

背景与目的:骨孤立性浆细胞瘤(SBP)少见,目前国内有关该病的相关临床报道较少。本研究对其特点与预后作一探讨。方法:收集1998—2007年北京大学第三医院确诊的12例SBP患者的临床资料,并对其临床特点、治疗及预后作一回顾性分析。结果:12例SBP患者年龄37～71岁,平均年龄49.6岁,男女比3∶1。免疫表型:11例表达CD79a,10例表达VS38C,均不表达CD20。随访12～87个月,平均随访时间(40±22)个月。4例(33%)转为多发性骨髓瘤,其中2例死于感染,中位存活时间73个月,3年和5年生存率分别为90%和75%。结论:SBP好发于中老年男性,预后较好,部分可转化为多发性骨髓瘤。

Background and purpose： Solitary plasmacytoma of bone （SBP） is a rare disease, reports releveant to this disease are rarely seen. The purpose of this study was to investigate the relation between the clinical features and the prognosis of solitary plasmacytoma of bone. Methods： We reviewed the data of 12 patients diagnosed with solitary plasmacytoma of bone from 1998 to 2007 in Peking University third hospital,the clinical features,treatment and prognosis of the patients were analyzed retrospectively. Results： The age ranged from 37-71 years （mean 49.6 years）, the male/female ratio was 3 to 1. Immunophenotype analysis showed that 11 （91.6%） cases were positive for CD79a, 10（83.3%） positive forVS38C, and all negative for CD20. With 12 to 87 months follow-up （average 40±22 months）, three cases （33%） developed to multiple myeloma, two of them died from infection, the median survival time was 73 months, the 3 year and 5 year survival rate were 90 percent and 75 percent respectively. Conclusion： Middle and old male are more likely to develop SP. The prognosis is good,but some of them can progress to multiple myeloma.