带状疱疹患者血清Th细胞因子的检测

Detection of Th Cytokine in Peripheral Blood of Patients with Herpes Zoster

目的分析机体细胞免疫功能与带状疱疹的关系。方法采用双夹心ELISA法测定带状疱疹患者血清IL-2,IL-4和TNF-α水平。结果患者血清IL-2,TNF-α水平均较正常对照组明显下降(P<0.001),IL-4水平较正常对照组明显升高(P=0.044);不同年龄和性别患者之间存在差异。结论带状疱疹患者存在血清Th细胞因子异常,外周血清Th1/Th2细胞因子水平明显失衡可能在带状疱疹的发生和发展中起重要作用;年龄可能是带状疱疹发生的危险因素。

Objective To analyse the relationship between virus infection and immune function and indicate the mechanism in pathogenesis of herpes zoster by investigating the change of serum level of Th cytokine. Methods The serum level of IL-2, IL-4 and TNF-α were detected by double antibody sandwich ELISA in patients with herpes zoster. Results Patients with herpes zoster had lower serum lever of IL-2 （ P 〈 0.001 ） and TNF-α （ P 〈 0. 001 ）, but had higher serum lever of IL-4 （ P = 0. 044） compared with that of normal controls, and in different age and gender of patients , the level of IL-2,IL-4 and TNF-αremained markedly different. Conclusion The Th1/Th2 cytokines in serum of patients with herpes zoster were in unbalance, which might play a great role in the pathogenesis and development of herpes zoster, and the incidence of herpes zoster （HZ） increased markedly with increasing age.