月桂酸-2-羟基-3-丙磺酸钠的合成

Synthesis of Lauric Acid-2-Hydroxy-3-Propane Sulfonic Acid Sodium Salt

以亚硫酸氢钠、环氧氯丙烷、磷酸钠和月桂酸为原料合成了月桂酸-2-羟基-3-丙磺酸钠,研究了反应温度、反应时间、催化剂用量、反应物摩尔比等对反应的影响,确定了合成目标产物的最佳方案为:亚硫酸氢钠与环氧氯丙烷的摩尔比为1.15∶1,环氧氯丙烷滴加到亚硫酸氢钠溶液中,85℃下滴加2 h,反应1.5 h,合成中间产物3-氯-2-羟基丙磺酸钠;3-氯-2-羟基丙磺酸钠加入到磷酸钠溶液中,55℃下反应4 h,合成中间产物2,3-环氧丙磺酸钠;2,3-环氧丙磺酸钠溶液滴加到月桂酸中,90℃下滴加0.5 h,反应2.5 h,合成月桂酸-2-羟基-3-丙磺酸钠,此时产率达85.2%,通过红外光谱对产物进行了表征。

Lauric acid-2-hydroxy-3-propane sulfonic acid sodium salt was synthesized by using sodium bisulfite,epichlorohydrin, sodium phosphate and laurie acid as raw materials. The influential factors, such as reaction temperature, reaction time, the amount of catalyst and reactant molar ratio were explored. The optimum method for synthesizing the objective compound was determined as follows：the molar ratio of sodium bisulfite to epichlorohydrin was 1.15 ： 1 ,firstly, epichlorohydrin solution was dropped into sodium bisulfite sloution for2 h and reacted for 1.5 h at 85~C to obtain 3- chloro-2-hydroxy-propane sulfonic acid sodium; secondly, 3-chloro-2-hydroxy-propane sulfonic acid sodium was dropped into sodium phosphate solution and reacted for 4 h at 55℃ to obtain 2,3-oxiranemethane sulfonic acid sodium salt;finally,2,3-oxiranemethane sulfonic acid sodium salt was dropped into lauric acid solution for 0. 5 h and reacted for 2. 5 h at 90℃ to obtain lauric acid-2-hydroxy-3-propane sulfonic acid sodium salt. The highest yield reached 85.2%. And the product was characterized by FTIR.