摘要
作为一种高效蛋白质降解途径，泛素-蛋白酶体系统（ubiquitin-proteasome system，UPS）在维持细胞功能方面具有重要作用。在认知功能的分子机制方面，UPS的作用正成为新的研究热点。UPS主要作用于神经递质及其受体、突触调节、突触后电位长时程增强以及神经细胞内信号转导等，有可能成为对认知功能障碍进行干预的新靶点。
As a highly efficient protein degradation pathway, ubiquitin-proteasome system （UPS） plays an important role in maintaining cell function. The role of UPS is becoming a new research focus in molecular mechanism of cognitive function. UPS mainly acts on neurotransmitter and its receptor, synaptic regulation, long-term potentiation of postsynaptic potentials and neuronal signal transduction, and it may become a new target for the intervention of cognitive dysfunction.
出处
《国际脑血管病杂志》
2008年第11期862-865,共4页
International Journal of Cerebrovascular Diseases
基金
国家自然科学基金（No.30772233）
关键词
泛素蛋白酶体系统
认知功能
分子机制
ubiquitin-proteasome system
cognitive function
molecular mechanism
