摘要
以间硝基苯甲醛、乙酰乙酸甲酯及合成的3-氨基-2-丁烯酸乙酯和间硝基苯甲醛、乙酰乙酸乙酯及3-氨基-2-丁烯酸甲酯在离子液体1-丁基吡啶四氟硼酸盐中环合合成第二代1,4-二氢吡啶类钙拮抗剂尼群地平,收率分别为93%和94%,离子液体回收套用至少3次,产物收率没有明显降低。
The second generation 1,4-dihydropyridine calcium antagonist Nitrendipine was synthesized through the condensation of 3-nitrobenzaldehyde,methyl acetoacetate and ethyl 3-aminocrotonate,or the condensation of 3-nitrobenzaldehyde,methyl acetoacetate and ethyl 3-aminocrotonate in an ionic liquid,n-butyl pyridinium tetrafluoroborate at 100-110℃ for 3 h in yield of 93% and 94%.The ionic liquid can be recycled in yield of 90%,and can be reused at least 3 times without loss in activity.
出处
《化工时刊》
CAS
2008年第12期14-16,共3页
Chemical Industry Times
基金
广东省卫生厅医学科学技术研究基金(B2007112)
关键词
1
4-二氢吡啶类钙拮抗剂
尼群地平
离子液体
1,4-dihydropyridine calcium antagonist nitrendipine synthesis ionic liquid
