摘要
目的探讨常规放疗加紫杉醇治疗胃癌的临床效果及毒副反应。方法回顾性分析我院2005年2月—2006年11月进行常规放疗加每周紫杉醇治疗的胃癌患者35例,放射治疗每周5次,每次1.8 Gy,总剂量43.2 Gy,对于残存肿瘤加量至50.4 Gy。紫杉醇每周1次,40 mg/m2,持续静滴3 h。结果35例按计划完成了治疗,总有效率为80%,1年总生存率为74%。放射性食管炎及胃炎是最常见的毒性反应,Ⅲ级6人(17%),Ⅳ级5人(14%)。结论常规放疗加紫杉醇治疗胃癌是有效的治疗方法,局部控制率好,毒副反应能够耐受,但远处转移的控制有待更进一步的研究。
Objective To evaluate the clinical effect and toxicity of radiotherapy and concomitant weekly paclitaxel for gastric cancer. Methods Thrity-five patients with gastric cancer, who were treated with radiotherapy and concomitant weekly paclitaxel between February 2005 and November 2006, were retrospectively analyzed. The patients, with a mean age of 51 （31 -81 ） years, consisted of 27 males and 8 females. Radiotherapy was administered with conventional technique, i.e. 1.8 Gy/day for 5 days/ week up to a total dosage of 43.2 Gy. Those who were medically inoperable received a radiation boost to 50.4 Gy. The dose of paclitaxel was 40 mg/m^2 once weekly （ intravenous drip over 3 hours）. Results Chemoradiotherapy was completed on 35 patients. The overall response rate was 80%. The 1-year survival rate was 74%. Esophagitis and gastritis were the two most important toxicity reactions [ Grade 3 in four patients （ 15 % ）, Grade 4 in three patients （ 11% ） ]. Conclusion Radiotherapy plus concomitant weekly paclitaxel is one of the safe and effective treatments for gastric cancer. It can revelive clinical sysptoms, and be well tolerated without severe side effects. The long term complications need to he further studied.
出处
《临床军医杂志》
CAS
2008年第6期927-929,共3页
Clinical Journal of Medical Officers
关键词
胃肿瘤
紫杉醇
放射治疗
gastric neoplasm
paclitaxel
radiotherapy
