期刊文献+

伊立替康联合卡培他滨治疗晚期结、直肠癌的疗效 被引量:1

下载PDF
导出
摘要 目的探讨伊立替康(CPT-11)联合卡培他滨治疗晚期结、直肠癌的疗效及安全性。方法40例晚期结、直肠癌患者采用卡培他滨2 000 mg/(m2.d),口服,2次/d,连服14 d;CPT-11 60 mg/(m2.d)加入生理盐水250 mL中静脉滴注90 min,第1、8天。每3周重复为1个周期,治疗3个周期后判断疗效。结果40例患者中,部分缓解(PR)11例(27.5%),稳定(SD)19例(47.5%),进展(PD)10例(25.0%)。中位疾病进展时间7.5个月,中位生存期13.6个月。腹泻Ⅲ-Ⅳ度27例(67.5%),恶心、呕吐Ⅲ-Ⅳ度12例(30.0%),白细胞降低Ⅰ-Ⅱ度36例(90.0%)。结论CPT-11联合卡培他滨治疗晚期结、直肠癌疗效较好,且不良反应可耐受。
作者 李春来
出处 《实用临床医学(江西)》 CAS 2008年第11期32-33,共2页 Practical Clinical Medicine
  • 相关文献

参考文献4

  • 1Jemal A, Tiwari R C, Murray T, et al. Cancer Statistics, 2004 [J].CA Cancer J Clin,2004,54(1) :8-29
  • 2Bouche O, Raoul J L, Bonnetain F, et al. Randomized Multicenter Phase Ⅱ trial of a Biweekly Regimen of Fluorouracil and Leucovorin (LV5FU2), LV5FU2 Plus Cisplatin, or LVSFU2 Plus Irinotecan in Patients with Previously Untreated Metastatic Gastric Cancer: A Federation Francophone de Cancerologic Digestive Group Study-FFCD 9803 [J]. J Clin Oncol, 2004,22 (21) : 4319-4328.
  • 3陈智伟,廖美琳.RECIST标准在肿瘤治疗疗效评价中的应用[J].中国肿瘤,2004,13(10):616-618. 被引量:171
  • 4Vanhoefer U, Harstrick A, Achterrath W, et al. Irinotecan in the Treatment of Colorectal Caeer: Clinical Overview[J].J Clin Onco1,2001,19(5) : 1501-1518.

二级参考文献8

  • 1WHO handbook for reporting results of cancer treatment [M].Geneva (Switzerland):World Health Organization,1979.
  • 2Duffaud F,Therasse P.New guidelines to evaluate the response to treatment in solid tumors[J].Bull Cancer,2000,87(12):869-870.
  • 3James K,Eisenhauer E,Christian M,et al.Measuring response in solid tumors:unidimensional versus bidimensional measurement[J].J Natl Cancer Inst,1999,91(6):523-528.
  • 4Mazumdar M,Smith A,Schwartz LH.A statistical simulation study finds discordance between WHO criteria and RECIST guideline[J].J Clin Epidemiol,2004,57(4):358-365.
  • 5Therasse P,Arbuck SG,Eisenhauer EA,et al.New guidelines to evaluate the response to treatment in solid tumors [J].J Natl Cancer Inst,2000,92(3):179-181.
  • 6Werner-Wasik M,Xiao Y,Pequignot E,et al.Assessment of lung cancer response after nonoperative therapy:tumor diameter,bidimensional product,and volume.A serial CT sean-based study[J].Int J Radiat Oncol Biol Phys,2001,51(1):56-61.
  • 7Prasad SR,Saini S,Sumner JE,et al.Radiological measurement of breast cancer metastases to lung and liver:comparison between WHO (bidimensional) and RECIST (unidimensional) guidelines [J].J Comput Assist Tomogr,2003,27(3):380-384.
  • 8Trillet-Lenoir V,Freyer G,Kaemmerlen P,et al.Assessment of tumour response to chemotherapy for metastatic coloreetal cancer:accuracy of the RECIST criteria[J].BrJ Radiol,2002,75(899):903-908.

共引文献170

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部