不同剂量雷莫司琼预防术后静脉镇痛恶心呕吐的临床效果观察

Effect of different doses of Ramosetron on postoperative nausea and vomiting during postoperative intravenous analgesia

目的比较不同剂量雷莫司琼预防术后静脉镇痛（PCIA）恶心呕吐的临床效果。方法选择ASAⅠ～Ⅱ级手术患者114例,随机分为A、B、C三组,每组38例。A组PCA配方为吗啡10 mg＋芬太尼0.8 mg＋雷莫司琼0.3 mg;B组PCA配方为吗啡10 mg＋芬太尼0.8 mg＋雷莫司琼0.6 mg;C组PCA配方为吗啡10 mg＋芬太尼0.8mg。结果A、B两组患者术后恶心呕吐发生率（5/38例,13.2%;4/38例,10.5%）均低于C组（13/38例,34.2%）且其差异有统计学意义（P〈0.05,P〈0.01）。A组恶心呕吐发生率（5/38例,13.2%）与B组恶心呕吐发生率（4/38例,10.5%）比较差异无统计学意义（P〉0.05）。结论雷莫司琼0.3 mg即可达到预防吗啡和芬太尼术后PCEA恶心呕吐的效果。

Objective： To investigate the effect of different doses of Ramosetron on reducing nausea and vomiting for patients＇ controling intravenous analgesia（PCIA）.Methods： One hundred and fourteen ASA Ⅰ～Ⅱ patients were randomly divded into there groups with thirty-eight cases each.The patients in group A were given PCIA with Ramosetron 0.3 mg in 100 ml,in group B by PCIA with 0.6 mg in 100 ml and in group C PCIA without Ramosetron.Nausea and vomiting were recorded at the same time points.Results： A significant reduce of incidence in nausea and vomiting was abserved in group A and B compared with that in group C.There was difference between group A and B（P〉0.05）.Conlusion： The dose of 0.3 mg of Ramosetron can reduce postoperative nausea and vomiting during PCIA.