养血清脑颗粒治疗慢性脑供血不足的临床疗效及对血液流变学的影响

Effect of Yangxue Qingnao granules on chronic cerebral circulation insufficiency and hemorrheology

目的观察养血清脑颗粒治疗慢性脑供血不足(CCCI)的临床疗效及其对血液流变学的影响。方法将慢性脑供血不足(CCCI)患者104例随机分为2组。在常规治疗基础上治疗组56例加服养血清脑颗粒,每次4g,每日3次口服。对照组48例在常规治疗基础上加服曲克芦丁,每次2片,每日3次口服。2组均30日为1个疗程。观察2组临床疗效,治疗前后血液流变学指标及大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、左右椎动脉(VA)和基底动脉(BA)的搏动指数(PI)及阻力指数(RI)的变化。结果2组治疗后全血黏度(低切)、血浆黏度,MCA、ACA、PCA的PI及MCA的RI及总有效率比较差异均有统计学意义(P<0.05)。结论养血清脑颗粒治疗慢性脑供血不足疗效确切,能降低CCCI患者的血液黏稠度及血液流变学指标,增加脑供血,缓解血管痉挛,改善临床症状,改善脑供血不足。

Objective To observe the effect of Yangxue Qingnao granules on chronic cerebral circulation insufficiency and hemorrheology. Methods 104 patients with chronic cerebral circulation insufficiency （CCCI） were randomly divided into two groups.In basis of routine therapy, patients in treatment group （ n = 56） were treated by Yangxue Qingnao granules,4 g,three times a day; patients in control group （ n = 48） were treated by Troxemtin, 3 pills a day.The course was 30 days in two groups.The indexes of hemorrheolcgy and MCA,ACA,PCA, VA, BA and PI were observed before and after treatment.Results There were significant differences between two groups in blood viscosity （in low shear rate）, plasma viscosity, MCA, ACA, PCA, MCA and PI after treatment （ P 〈 0.05） . Conclusion Yangxue Qingnao granules have definite effect on chronic cerebral circulation insufficiency, and decrease and hemorrheology in patients with CCCI, relieve angiospasm and improve clinical symptoms.