CyclinD_1、P27^(KIP1)在不同病理类型胃息肉和胃癌中的表达及相关性的探讨

RELATIONSHIP AND EXPRESSION BETWEEN THE Cyclind_1 AND THE P27^(KIP1) IN POLYPS AND STOMACH NEOPLASM

目的:探讨不同病理类型胃息肉发生癌变的类型及Cyclind1、p27kip1在不同病理类型胃息肉、胃癌中表达和相关性。方法:采用S-P免疫组化方法检测Cyclind1、p27kip1在10例正常胃黏膜、20例慢性胃炎、40例胃息肉、40例胃癌中的表达。结果:(1)Cyclind1、p27kip1与胃癌的发生发展关系密切。(2)腺瘤型胃息肉与高分化胃癌关系密切。结论:(1)检测Cyclind1、p27kip1可以作为诊断与评估胃息肉和胃癌发生、发展类型的主要指标之一。(2)胃癌的发生可能与抑癌基因p27kip1的失活和原癌基因Cyclind1的激活有关。

Objective： To evaluate the relation of the Cyclind1 and the p27^kip1 expression in gastric polyps and stomach neoplasm. Methods：Immunohistochemical method（ s- p）was used to detect the expression of cyclind, p27^kip1 in 10 eases of normal gastric mucosa, 20 cases of chronic superficial gastritis, 40 cases of gastric polyps and 40 cases of gastric carcinoma. Results： （ 1 ） There was a relationship between cyclind1 and p27^kip1 expression in stomach cancer. （2）The gastric adenomotous polyps was closely related with advanced adenoearcinoma. Conclusion：（ 1 ）The data show the expression of Cyclind1 and p27^kip1 are involved in the genesis and progression of stomach polyps and stomach cancer. Cyelind1 and p27^kip1 may be prognostic indicator of stomach cancer. （2）There was a relationship between the activation of oncogene cyclind1 and inactivation of tumor suppressor gene p27^kip1 in stomach neoplasm.