新疆牧区哈萨克族与蒙古族低密度脂蛋白胆固醇水平调查与影响因素分析

Comparison of low density lipoprotein cholesterol levels in Kazaks and Mongolians from Xinjiang pastoral area

目的调查新疆牧区哈萨克族、蒙古族低密度脂蛋白胆固醇（LDL—C）水平，观察其差异，分析其影响因素。方法采用整群随机抽样的方法选取新疆和丰县牧区年龄≥30岁的牧民632人为调查对象，其中哈萨克族325人，蒙古族307人；抽取空腹12h静脉血3ml，采用日立7600全自动生化分析仪测定血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）的浓度，并根据公式计算出LDL-C的浓度，对资料进行汇总，并采用t检验、方差分析或协方差分析的方法观察两民族间血浆LDL—C水平的差异，并进一步采用多元逐步回归分析的统计方法研究其影响因素。结果哈萨克族、蒙古族的LDL-C平均水平分别为（3．68±1．16）mmol／L和（3．29±1．23）mmol／L，两民族间LDL—C平均水平存在明显的差异（P〈0．001）；哈萨克族人群中LDL—C水平主要与平均动脉压相关，而蒙古族主要与体质指数密切相关。结论血浆LDL—C水平受多种因素的影响，存在明显的民族差异，即便是主要劳动方式和生活习惯十分相似的民族间LDL-C水平的主要影响因素也各不相同。

Objective To compare the serum levels of low density lipoprotein cholesterol in Kazaks and Mongolians from Xinjiang pastoral area. Methods A randomized cluster sampling was performed to obtain a representative sample of population in Xinjiang Hefeng pastoral area. Blood was taken from 632 individuals aged 30 and older for measurements of total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C） by automatic biochemical analyzer. The serum levels of low density lipoprotein cholesterol（LDL-C） was calculated according to the formula. Results The mean serum level of LDL-C was significantly higher in Kazaks [ （3.68 ± 1.16 ） mmoL/L] than that in Mongolians[ （3.29 ± 1.23 ） mmol/L, P 〈0. 001 ]. The serum levels of LDL-C in Kazaks were significantly associated with mean artery pressure. The serum levels of LDL-C in Mongolians were significantly associated with body mass index. Conclusion The serum levels of LDL-C were higher in Kazaks compared that in Mongolians in Xinjiang pastoral area.