颌骨放射性骨坏死研究进展

Research advances in osteoradionecrosis of the jaw

颌骨放射性骨坏死是头颈肿瘤放疗后常见的并发症之一,以下颌骨最为常见。其发展慢、病程长,因发病机制至今未能完全明确,目前缺乏针对性治疗,多数患者需要通过手术切除病损,往往造成颌面部软硬组织缺损,给患者带来极大痛苦,严重影响肿瘤患者治疗后的生存质量。本文就其发病机制、预防、诊断和治疗的研究进展作一综述。

Osteoradionecrosis is a common postirradiation complication of head and neck cancer treatment. It occurs predominantly in the mandible. The development of osteoradionecrosis is slow and can persist for a long time. No etiological treatment is found because the pathogenesis of the diseases is not clear. Resection of the lesion is the common option for most patients. The quality of life of the patients is impaired because of the defect of the soft and osseous tissues in head and neck. This review focused on the research advances in the pathogenesis, prevention, diagnosis and treatment of the osteoradionecrosis.