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柠檬酸盐抗凝剂对机体代谢的影响 被引量：8

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摘要 成分血单采技术（又称机采）已广泛应用于各采供血机构及各临床医疗单位。作为一种标准配置的抗凝剂，柠檬酸盐（ACD—A）常规地应用在各机采过程中。有关柠檬酸盐的应用可引起成分血单采过程中献血者低钙血症的现象已有报道，但至今为止仍缺乏具对照性的动力学研究。因此，对该抗凝剂在应用过程中所带来的钙离子及其他电解质的详细代谢变化过程还知之甚少。鉴于新近报道指出柠檬酸盐抗凝剂的应用可能引起机体骨代谢的变化，详尽了解该抗凝剂的代谢影响显得十分必要。
作者 陈颖 曾嘉 Dettke Markus
机构地区 福建省血液中心 Department of Blood Group Serology and Transfusion Medicine
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2008年第12期1382-1384,共3页 Chinese Journal of Laboratory Medicine
关键词 柠檬酸盐 机体代谢 抗凝剂 采供血机构 医疗单位 标准配置 低钙血症 代谢变化
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献9

  • 1Winters JL. Complications of Donor Apheresis. J Clin Apher, 2006, 21:132-141.
  • 2Makar YF, Butler MO, Cockersole GM, et al. National audit of citrate toxicity in plateletpheresis donors. Transfus Med ,2002,12: 183-191.
  • 3孙启俊,傅强,李翠萍,欧阳建,陈津,周丽娟,张晓萍,王瑛瑛,姜士荣,朱世钧,张葵.长期机采血小板献血者甲状旁腺素测定的意义[J].中国输血杂志,2005,18(6):468-469. 被引量：19
  • 4Das SS, Chaudhary R, Khetan D, et al. Calcium and magnesium levels during automated plateletpheresis in normal donors. Transfus Med, 2005,15:233-236.
  • 5Bolan CD, Greer SE, Cecco SA, et al. Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion, 2001, 41:1165-1171.
  • 6Wang PL, Meyer MM, Orloff SL, et al. Bone resorption and "relative" immobilization hypercalcemia with prolonged continuous renal replacement therapy and citrate anticoagulation. Am J Kidney Dis, 2004, 44 : 1110-1114.
  • 7Dettke M, Buchta C, Bieglmayer C, et al. Short and long term effects of citrate on bone metabolism and bone mineral density in healthy plateletpheresis donors. J Clin Apher, 2003, 18 : 87.
  • 8Morrison B, Shenkin A, Mclelland A et al. Intra-Individual variation in commonly analyzed serum constituents. Clin Chem, 1979, 25 : 1799-1805.
  • 9陈颖,Markus Dettke,Paul Hoecker,Christian Bieglmayer.血小板机采过程中年龄依赖性骨代谢变化分析[J].中华检验医学杂志,2007,30(8):878-881. 被引量：10

二级参考文献16

  • 1Toby L, Simon Bruce C, McLeod. Physiology of Apheresis. In: McLeod BC, Price TH, Drew MJ, eds. Apheresis.. principles and practice Bethesda: AABB Press, 1997,67-79.
  • 2张素华 叶任高 陆再英主编.原发性甲状旁腺功能亢进症[A].叶任高,陆再英主编.内科学·第6版[C].人民卫生出版社,2004.764-767.
  • 3Goodman WG, Frazao JM, Goodkin DA, et al. A calcimimeticagent lowers plasma parathyroidhorm one evels in patients with secondary hyperparathyroidism. Kidney Int, 2000, 58(1): 436.
  • 4Slatopolsky E, Brown A, Dusso A. Role of phosphorus in the pathogenesis of secondary hyperparathyroidism J. Am J Kidney Dis, 2001, 37(1 Suppl 2):54-57.
  • 5Winters JL. Complications of Donor Apheresis. J Clin Apher, 2006,21:132-141.
  • 6Stohlawetz P, Stiegler G, Jilma B, et al. Measurement of the levels of reticulated platelets after plateletpheresis to monitor activity of thrombopoiesis. Transfusion, 1998,38:454-458.
  • 7Lazarus EF, Browning J, Norman J, et al. Sustained decreases in platelet count associated with multiple, regular plateletpheresis donations. Transfusion,2001,41:756-761.
  • 8Dettke M, Buchta C, Bieglmayer C, et al. Short and long term effects of citrate on bone metabolism and bone mineral density in healthy plateletpheresis donors. J Clin Apher,2003,18: 87.
  • 9Bolan CD, Greer SE, Cecco SA, et al. Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion,2001,41 : 1165-1171.
  • 10Bolan CD, Cecco SA, Yau YY, et al. Randomized placebocontrolled study of oral calcium carbonate supplementation in plateletpheresis:Ⅱ. Metabolic effects. Transfusion, 2003,43: 1414-1422.

共引文献23

同被引文献90

引证文献8

二级引证文献27

中华检验医学杂志
2008年 第12期

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