摘要
目的:比较坦度螺酮与多虑平治疗焦虑症的疗效和不良反应。方法:60例焦虑症患者随机分为坦度螺酮组和多虑平组,每组各30例;分别给予坦度螺酮和多虑平治疗。疗程4周。于治疗前及治疗1、2、4周采用汉密尔顿焦虑量表(HAMA)和治疗中出现的症状量表(TESS)评定临床疗效和不良反应。结果:坦度螺酮组总有效率和显效率分别为83.3%和46.7%,明显高于多虑平组的60.0%和36.7%(P<0.05);坦度螺酮组和多虑平组HAMA评分治疗前分别为(28.3±6.1)分和(29.2±5.7)分,治疗4周,分别下降至(10.9±4.6)分和(15.8±5.1)分,两组均有效但以坦度螺酮组显著为好(P<0.05)。两组不良反应发生率以坦度螺酮组较多虑平组少而轻。结论:坦度螺酮治疗焦虑症疗效明显好于多虑平,显效快,不良反应少。
Objective：To compare the effects and adverse reactions of tandospirone and doxepin in treating anxiety neurosis. Method：60 cases with anxiety neurosis were randomly divided into two groups （tandospirone and doxepin）. Effects and adverse reactions were evaluated with hamiltom anxiety scale （HAMA）and treatment emergent symptoms scale（TESS） before and after treatment. Results：The marked effective rate and total effective rate were 46.7% and 83.3% respectively in tandospirone group and were significantly higher than those in doxepin group 36.7 and 60.0% respectively （ P 〈 0.05 ）, The adverse reactions in tandospirone group were less than those in doxepin group. Conclusion： Tandospirone shows better and faster efficacy and less adverse reactions than doxepin in treating anxiety neurosis.
出处
《临床精神医学杂志》
2008年第6期413-414,共2页
Journal of Clinical Psychiatry
关键词
焦虑症
坦度螺酮
多虑平
anxiety neurosis
tandospirone
doxepin
