实验性淋巴细胞白血病鸡外周血淋巴细胞GRmRNA表达

GRmRNA Expression of Peripheral Blood Lymphocytes in Chickens with Experimental Lymphoid Leukosis

为研究糖皮质激素抵抗在淋巴组织增生性疾病发生中的作用，以禽淋巴细胞白血病病毒（ＬＬＶ）ＲＡＶ－１株接种１日龄母鸡雏，定期检测其血浆皮质酮、淋巴细胞ＧＲｍＲＮＡ和ＧＲ相对含量。结果表明，在淋巴细胞性白血病发病期，ＧＲｍＲＮＡ和ＧＲ相对含量分别下降２１．７％和２７．３％，而血浆皮质酮水平未发生改变。研究结果提示，ＬＬＶ诱导鸡淋巴细胞发生糖皮质激素抵抗可能是禽淋巴细胞白血病发生的机理之一。

In order to investigate the effect of glucocorticoid resistance on lymphoproliferative diseases, the relative contents of GR and GRmRNA of the peripheral blood lymphocytes were detected for six months in chickens infected with RAV1 strain of lymphoid leukosis virus (LIV) at 1dayold age. The results showed that the levels of GR and GRmRNA of LLVinfected chickens declined by 21.7% and 27.3% respectively while the plasma corticosterone concentration was unchanged. These data suggested that glucocorticoid resistance of the lymphocyte induced by LLV may be a contributive factor for lymphoproliferation of the chicken with leukosis.