乳腺癌间质细胞的特征及其对肿瘤细胞的调控

Character of breast cancer stromal cells and regulation on tumor cells

肿瘤的发生与其周围组织细胞及细胞外基质等微环境的改变密切相关。肿瘤间质细胞不仅充当支持者的角色,而且直接或间接作用于肿瘤实质细胞,包括对肿瘤生长的抑制或促进作用及调控肿瘤上皮细胞的恶性表型等,从而参与肿瘤的发生、发展和转移。鉴于肿瘤间质细胞对于肿瘤细胞复杂的调控效应,近年来相关研究逐渐深入。

Contrary to being an idle bystander, the surrounding tumor microenvironment or stroma, actively participates in, and contributes to tumor progression directly or indirectly. It is evident that tumor stromal cells exhibit specific tumor- suppressive and tumor-promoting abilities that serve to regulate neoplastic growth of the epithelium. Due to the mounting evidence demonstrating the far-reaching effects of stroma during the process of malignant transformation, the involvement of stroma in cancer progression has become an area of intense investigations in recent years.