磁共振灌注成像在胰腺癌中的应用初探

Application of Magnetic Resonance Perfusion Weighted Imaging in Pancreatic Adenocarcinoma

探讨磁共振灌注成像在胰腺癌诊断中的应用价值。胰腺癌患者34例,健康志愿者28例,采用VIBE序列进行全胰腺灌注成像,通过胰腺癌和正常胰腺各感兴趣区的时间-信号曲线,计算各感兴趣区的峰值时间(TTP)、最大斜率(SS),比较胰腺癌与正常胰腺的灌注值差别。胰腺癌TTP值为140.24±24.14s、正常胰腺TTP值为24.33±3.74s,两者间有统计学差异(P<0.05);胰腺癌和正常胰腺的SS值分别为16.10±2.20、30.23±4.66,两者间亦有统计学差异(P<0.05)。相对正常胰腺,胰腺癌的TTP显著延长,SS明显降低。磁共振灌注成像可以在活体无创的评估胰腺血供。

To assess the value of MR perfusion weighted imaging in diagnosis of pancreatic adenocarci- noma. Thirty - four patients with pancreatic adenocarcinoma and twenty - eight healthy volunteers underwent MR perfusion with sequence VIBE. A region of interest（ROI） was drawn in adenocarcimoma and normal pancreas respectively, then their time - intensity curves（TIC） were got. The time to peak（TTP） and the steepest slope（SS） were calculated. Then the following statistical analyses were performed： perfusion gained with adenocarcinoma and normal pancreas. The TTP of adenocarcinoma and normal pancreas were 140.24±24.14s, 24.33±3.74s respectively, and the SS 16.10±2.20, 30.23±4.66. There was a significant difference between perfusion of adenocarcinom and normal pancreas（P 〈 0.05） . MR perfnsion weighted imaging can be used to analyze pancreatic blood supply in vivo without invasion. Compared with normal pancreas, pancreatic carcinoma has a prolonged TTP and a lower SS.