摘要
目的研究三氧化二砷(As2O3)对人结肠癌裸鼠肝转移的抑制作用。方法BALB/C-nu/nu裸鼠经脾脏接种人结肠腺癌LS-174T细胞建立结肠癌裸鼠肝转移模型,于10min(早期)、10天(中期)、20天(晚期)经尾静脉注射As2O3,对照组注射生理盐水。观察各组裸鼠体重变化、肝转移结节的数目、大小、瘤重以及肝脏肿瘤替代率和荷瘤鼠的生存时间。结果与对照组相比,早期及中期治疗组裸鼠肝转移结节的数目、大小、瘤重以及肝脏肿瘤替代率和荷瘤鼠的生存时间差异均有统计学意义(P<0.05),晚期治疗组差异无统计学意义(P>0.05)。结论三氧化二砷对人结肠癌裸鼠肝转移有明显的抑制作用,早期效果优于中晚期。
Objective To explore the inhibitory effect of As2O3 on liver metastasis from human colon cancer in nude mice. Methods BALB/C-nu/nu nude mice model of liver metastasis from colon cancer was established. As2O3was injected into nude mice 10 minutes, 10 clays and 20 days after the animals inflicted with liver metastasis from colon cancer. The weight of the nude mice, the number, size and weight of the hepatic metastatic lesions,the percentage of hepatic replacement by tumour and the survival period were observed. Results The number, size, weight of the hepatic metastatic lesions were obviously inhibited by As2O3 in early time and metaphase; the percentage of hepatic replacement by tumour was decreased and the survival period of tumor-loading nude mice was prolonged compared with the control（P〈0. 05）. Conclusion As2O3 can inhibit the live metastasis from human colon cancer in nude mice and early treatment could be more efficient than metaphase and later.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2008年第12期842-844,共3页
Cancer Research on Prevention and Treatment
