摘要
目的探讨maspin在宫颈鳞状细胞癌中的表达及其意义。方法采用免疫组化染色技术检测10例正常宫颈、16例宫颈息肉、13例宫颈糜烂及58例宫颈癌标本中maspin蛋白表达。结果maspin蛋白在10例正常宫颈中表达,在宫颈息肉和宫颈糜烂中高表达(81.25%,84.61%),正常宫颈、宫颈息肉和宫颈糜烂三者无显著性差异(P>0.05),而在宫颈癌组织中maspin蛋白表达下调(36.21%,P<0.01)。在宫颈癌组中,FIGO分期Ⅰ、Ⅱ期组maspin蛋白表达率高于Ⅲ、Ⅳ期组(P<0.05),伴宫颈旁淋巴结转移组maspin蛋白表达率低于无淋巴结转移组(P<0.05)。结论maspin对宫颈癌的发生、发展可能有一定的抑制作用。
Objective To explore the significance of maspin expression in cervix squamous carcinoma. Methods SIP immunohistochemical method was used to assess the expressicn of maspin in 10 cases normal cervix mucous, 16 cases of cervical polyp, 13 cases of cervical erosion and 58 cases of uterine cervix cancer patients. Results Positive expression was found in all the normal cases, high rate of positive expression was found in cervical polyp cases and cervical erosion cases （81.25%, 84. 61%）. While in 58 cases of uterine cervix cancer, the expression of maspin protein downregulate to 36. 21 % （P〈0. 01）. In the group of uterine cervix cancer, the expression of maspin in Ⅰ ＋ Ⅱ stages was higher than that in Ⅲ ＋ Ⅳ （P〈0. 05）. The expression of maspin protein in uterine cervix cancer with metastasis of lymph nods was lower than that in uterine cervix cancer without metastasis （P〈0. 05）. While the age of the patients and the histological grade didn＇t change the expression of maspin protein obviously. Conclusion Maspin maybe a suppressor to the cancer genesis and progression of uterine cervix cancer.
出处
《华中医学杂志》
2008年第6期401-403,共3页
Central China Medical Journal
