复方银杏叶胶囊对大鼠肝损伤的防护作用

Effects of compound Ginkgo Biloba capsule on liver injury in rats

目的:观察复方银杏叶胶囊(CGB)的保肝作用。方法:采用大鼠免疫性肝损伤模型,比较CGB与银杏叶提取物(GB)对大鼠肝脏功能保护作用。结果:CGB高、中剂量组大鼠血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、总胆红素(TBil),与模型组比较,差异均有显著性意义(P<0.05或P<0.01);GB组大鼠血清ALT、ALP、TBil与模型组比较,差异均有显著性意义(P<0.05或P<0.01),但AST与模型组比较差异无显著性意义(P>0.05)。结论:CGB与GB均有改善免疫性肝损伤大鼠肝功能效应,但CGB作用优于GB。

Objective： To study the effects of compound Ginkgo Biloba capsule （CGB） and Ginkgo Biloba extract （GB） on immunological liver injury in rats. Methods： Immunological liver injury was induced by injection of feral rat liver homogenate （FRL） 0.5ml, 60d, in rats, then CGB750mg·kg^-1, 250mg·kg^-1, 125mg·kg^-1, po, 60d, GB 66mg·kg^-1, po, 60 d. The alanine aminotransferase （ALT）, the aspartic transaminase （AST）, the alkaline phosphatase （ALP）, the bilirubin （TBil）, the albumin （Alb） were assayed by spectroscopy. Results： The AST, ALT, ALP and TBil level in groups of CGB 750mg ·kg^-1, 250mg·kg^-1 were decreased significantly （P 〈 0. 05 or P 〈 0. 01 ）, but the AST in groups of GB was not showed （P 〉 0. 05 ） . Conclusion： The results demonstrate that CGB and GB both have protective effects on feral rat liver homogenates-induced hepatic injury in rats and the protective effects of CGB is superior to that of GB.