逐瘀通脉胶囊治疗椎-基底动脉供血不足临床疗效及脑血流动力学变化分析

The Analysis of the changes for cerebral hemodynamics and the clinical effectiveness of Vertebrobasilar Insufficiency by the treatment of Zhuyutongmai Capsule

目的观察逐瘀通脉胶囊治疗椎—基底动脉供血不足临床疗效及脑血流动力学变化。方法将86例椎—基底动脉供血不足患者,随机分为2组,各43例,对照组给予甲磺酸倍他司汀片或盐酸氟桂利嗪胶囊等常规药物治疗;治疗组在对照组治疗基础上加用逐瘀通脉胶囊,2粒/次,3次/d,口服。2组均连用14d后观察疗效及血液流变学,同时TCD检测椎—基底动脉血流速度。结果治疗组疗效明显优于对照组(P<0.05);而且治疗组血液流变学各项指标及椎—基底动脉血流速度比对照组有明显改善(P<0.01)。结论逐瘀通脉胶囊与西药合用较单纯西药治疗椎—基底动脉供血不足能更有效地改善脑血流,促进脑血液循环,疗效更好。

Objective To observe the changes for cerebral hemodynamics and the clinical efficiency of Vertebrobasilar Insufficiency by the treatment of Zhuyutongmai Capsule. Methods 86 cases with Vertebrobasilar Insufficiency were randomly divided into 2 groups ： comparative group （ n = 43 ） that were treated by traditional western medicine therapy; Observation group（ n = 43 ）that treated by Zhuyutongmai Capsule, two capsules each time,tid × 14d, po. Both of observation and comparative groups were determined for the clinical efficiency and the level of hemodynamics after 14 days, and the blood flow velocities of basilar artery （BA） were measured by transcranial Doppler （TCD） . Results The therapeutic effect of observation group was significantly higher than that in comparative group（ P 〈 0.05 ）. And the blood flow velocities and the levels of hemodynamics increased obviously of observation group （ P 〈 0. 01 ）. Conclusion It was suggested that Zhuyutongmai capsule with western medicine could be effective and safe for VBI. And the blood flow of brain was improved.