兰索拉唑治疗反流性食管炎临床观察

A clinical study of lansoprazole in the treatment of reflux esophagitis

目的探讨兰索拉唑治疗反流性食管炎效果。方法将603例经胃镜检查确诊为反流性食管炎,将同意正规治疗、复查的患者随机分2组,治疗组服用兰索拉唑15mg,2次/d,西沙必利10mg,3次/d;对照组服用法莫替丁20mg,2次/d,西沙必利10mg,3次/d。治疗8周后复查胃镜,观察镜下愈合率和临床症状消除率。结果治疗组症状改善总有效率为80.1%,Ⅰ级为93.3%,Ⅱ级为82.9%,Ⅲ级为72.7%;镜下黏膜总愈合率为79.0%,Ⅰ级为93.3%,Ⅱ级为83.8%,Ⅲ级为68.2%。对照组症状改善总有效率为68.9%,Ⅰ级84.6%,Ⅱ级69.6%,Ⅲ级57.7%;镜下黏膜总愈合率为64.9%,Ⅰ级76.9%,Ⅱ级65.9%,Ⅲ级53.8%。结论兰索拉唑是治疗反流性食管炎的有效药物。

Objective To investigate the clinical effects of lansoprazole in treatment of reflux esophagitis. Methods 603 patients with reflux esophagitis diagnosed with gastroscopy , which agreed with reexamination after the regular treatment,were randomly divided into treatment group and control group. The patients of treatment group were given each 15mg of lansoprazole b. i. d. PO combined with cisapride t. i. d. PO, but the patients of control group were given each 20mg of famotidine b. i. d. PO combined with cisapride t. i. d. PO. After 8 weeks, gastroscope was performed to study the healing rate and symptom relief rate. Resuits The total symptom relief rate of the treatment group was 80.1% , but that of type Ⅰ , type Ⅱ and type Ⅲ was 93.3% ,82.9% and 72.7% respectively;the total effective rate as shown by gastroscopy was 79.0% , but that of type Ⅰ ,type Ⅱ and type Ⅲ was 93.5% ,83.8% and 68.2% respectively. The total symptom relief rate of control group was 70.1% ,but that of type Ⅰ ,type Ⅱ and type Ⅲ was 84.6% ,69.6% and 51. 7% respectively;the total effective rate as shown by gastroscopy was 64.9% ,but that of type Ⅰ ,type Ⅱ and type Ⅲ was 76.9% ,65.9% and 48.3% respectively. The difference between 2 groups was significant. Conclusion Lansoprazole is effective in the treatment of reflux esophagitis.