达那唑栓治疗子宫内膜异位症的临床分析

The Clinical analysis of danazol plug on the treatment of EMT

目的观察达那唑栓治疗子宫内膜异位症(EMT)的疗效及不良反应。方法2003年1月-2006年5月应用达那唑栓治疗子宫内膜异位症患者64例:达那唑栓50mg,第一个月每晚2粒,之后每晚1粒,阴道或肛门用药,对照组40例口服达那唑胶囊:达那唑胶囊200mg,每8h1次口服,3个月为1疗程。结果采用达那唑栓治疗组64例,总有效率达93.8%,口服达那唑胶囊治疗组40例,总有效率达92.5%,2组比较无显著性差异(P>0.05)。而栓剂组由于阴道或肛门用药的药量较小,仅为口服的1/12,未发现明显不良反应,不影响排卵,后者不良反应明显,造成闭经有显著差异(P<0.05)。结论达那唑栓治疗子宫内膜异位症安全、有效,值得推广应用。

Objective To analyze the effectiveness and side effect of danazol plug on the treatment of EMT. Methods Danazol plug was applied to 64 EMT patients in the period of January 2003 to May 2006. Danazol plug was used at 50mg twice a day within vagina or anal in the first month and once thereafter. 40 EMT subjects were applied with danazol capsule at 200mg orally every 8 hours for 3 months. Results The total effectiveness of danazol plug in the 64 EMT patients with vagina or anal application was 93.8%. The effectiveness in the 40 EMT patients treated with oral application was 92.5%. There is no significant difference between the two groups （ P 〉 0.05 ）. The amount of danazol used in the vagina and anal route was 1/12 of the oral group but without obvious side effect and not affecting ovulationl The oral application of danazol has more side effect with amenorrhea than the other group （P 〈 0. 005 ）. Conclusion Danazol is an efficient and safe drug for the treatment of EMT and worth wide - spread application.