原发性骨质疏松症与动脉钙化相关性的研究进展

Progress in relationship of osteoporosis and aorta calcification

骨质疏松症与动脉钙化均为老龄人口中发病率较高的慢性退行性疾病，且均具有较高的致残及致死率。目前已有大量证据提示两者之间存在一定联系。在动脉钙化及骨质疏松发生过程中均涉及到一些相同的蛋白及细胞因子。本文就骨质疏松与动脉钙化之间相关性，包括临床上的联系及共同的病理生理学机制进行了综述。基于两种疾病间的相关性，目前已有研究证实某些药物在增加骨量的同时可以减少动脉钙化的进展，这将对老年性疾病的综合防治具有重要意义。

Osteoporosis and vascular calcification are both chronic degenerative diseases and widely prevalent in aging population which induce high morbidities and mortalities. At present, growing evidence indicates the existence of a correlation between osteoporosis and vascular calcification. The mechanism of arterial calcification resembles the process of osteoporosis, involving the same proteins and cytokines that lead to tissue mineralization. This article reviews their clinical relationships, and presents some underlying physiopathological mechanisms that may account for the developments of both osteoporosis and vascular calcification. Current therapeutic approaches emerging from these linkages, including statins, bisphosphonates, and vitamin K, can enhance bone density and reduce atherogenesis, with attendant benefits to both indi- vidual and society.