原发性高血压肾病患者血清leptin与脂联素水平相关性分析

Relationship Between Serum Leptin and Adiponectin Levels in Patients with Primary Hypertensive Nephropathy

目的:探讨了原发性高血压肾病患者血清瘦素(leptin)水平与脂联素水平的相关性。方法:分别应用放射免疫分析和ELISA对84例原发性高血压患者(其中34例为伴肾病组,50例为无肾病组)进行了血清leptin和脂联素测定,并与35名正常健康人作比较。结果:原发性高血压无肾病组和肾病组血清leptin水平均非常显著地高于正常人组(P<0.01)。而血清脂联素水平则明显低于正常人组(P<0.01)。原发性高血压肾病组与无肾病组亦有显著性差异(P<0.05)。结论:原发性高血压的发生与血清leptin水平和血清脂联素水平有密切的关系。

Objective To explore the relationship between sentm leptin and adiponeetin levels in patients with primary hypertensive nephrophy. Methods Serum leptin （with RIA） and serum adiponeetin （with ELISA） levels were measured in 34 patients with primary hypertensive nephropathy, in 50 patients with essential hypentension but no nephropathy, as well as in 35 controls. Results Serum leptin levels in the patients were significantly higher than those in controls （ P 〈 0.01 ）. While the serum adiponeetin levels were significantly lower than those in controls （P〈0.01）. Among the patients, serum leptin levels were significantly higher in subject with nephropathy than those in subjects without nephropathy （P〈0.05） while the reverse was true for adiponeetin （P 〈0.05）. Conclusion The development of primary hypertensive nephrophy is correlated with a higher serum leptin and a decreased serum adiponectin levels.