慢性硬膜下血肿引流液检测NSE的应用价值

Clinical Usefulness of Determination of NSE Contents in Drainage Fluid of Patients with Chronic Subdural Hematoma

目的:观察慢性硬膜下血肿(CSDH)患者引流液的神经元特异性烯醇化酶(NSE)的浓度,及其与血清NSE浓度的关系。方法:收集CSDH患者经钻颅所产生的引流液,同时采集病人和正常对照者的血液,经处理后采用放免法测定NSE的浓度。结果:CSDH患者组的血清NSE高于正常对照组(P<0.01);CSDH患者引流液的NSE与自身血清NSE相关(r=0.917),引流液NSE高于自身血清NSE(P<0.01)。结论:测定CSDH患者引流术后的引流液NSE浓度变化可以作为疗效观察的指标之一。

Objective To investigate the relationship between the neuron - specific enolase （NSE） contents of serum and drain-age fluid in patients with chronic subdural hematoma （CSDH）. Methods Serum and drainage fluid NSE contents were determined with RIA right after and 24, 48, 72, 96, 120 hours after trephining in 28 patients with CSDH as well as 28 controls （once and serum only）. Results The serum contents of NSE in the patients were significantly higher than those in the controls （P〈0.01）. The drainage fluid contents of NSE were correlated with the patients concurrent own serum NSE contents （r=0.917） and were higher than the respcctive serum NSE value （P〈0.01）. All the NSE contents dropped continuously throughout the observation period. Conclusion Changes of drainage fluid NSE contents might reflect progress of the degree of nervous tissue injury in patients with chronic subdural hematoma.