血浆ET、Hcy和hs-CRP联检在冠心病诊治中的应用

Clinical Diagnostic Value of Determination of Plasma ET,Hcy and Serum hs-CRP Contents in Patients with Coronary Heart Diseases

目的:探讨了血浆内皮素(ET)、同型半胱氨酸(Hcy)和血清超敏C反应蛋白(hs-CRP)联检对冠心病的诊断价值。方法:分别应用放射免疫分析和免疫比浊法对38例冠心病患者进行了血浆ET、Hcy和血清hs-CRP检测,并与35名正常健康人做比较。结果:冠心病患者血浆ET、Hcy和血清hs-CRP水平均非常显著地高于正常人组(P<0.01),冠心病患者血浆ET水平与Hcy和hs-CRP水平呈正相关(r=0.6122、0.5842,P<0.01)。结论:检测冠心病患者血浆ET、Hcy和hs-CRP水平的变化对观察病情和预后判断具有重要的临床价值。

Objective To study the clinical diagnostic value of determination of plasma ET, Hcy and serum hs-CRP contents in patients with coronary heart disease （CHD）. Methods Plasma ET, Hey （with RIA） and serum hs-CRP （with immune turbidimetry） contents were determined in 38 patients with CHD and 35 controls. Results Plasma ET, Hey and serum hs - CRP concentration were significantly higher in CHD patients （than those in controls P 〈 0.01 ）. Plasma ET levels were significantly positively correlated with those of plasma Hey and serum hs-CRP （r=0.6122,0.5842, P〈0.01）. Conclusion Detection of changes of plasma ET, Hey and serum hs-CRP levels might be of prognostic importance in patients with CHD.