急性白血病患者治疗前后血清IGF-Ⅱ和血浆VEGF检测的临床意义

Clinical Significance of Determination of Changes of Serum IGF-Ⅱ and Plasma VEGF Levels After Treatment in Patients with Acute Leukemia

目的:探讨急性白血病患者治疗前后血清IGF-Ⅱ和血浆VEGF水平的变化及临床意义。方法:分别应用放射免疫分析和酶联法对32例急性白血病患者进行治疗前后血清IGF-Ⅱ和血浆VEGF的测定,并与35名正常健康人作比较。结果:急性白血病患者在治疗前血清IGF-Ⅱ和血浆VEGF水平非常显著的高于正常人组(P<0.01),经化疗和中西医结合治疗后6个月与正常人组比较仍有显著性差异(P<0.05)。结论:急性白血病的发生与发展与血清IGF-Ⅱ和血浆VEGF水平密切相关。

Objective To investigate the changes of serum IGF-Ⅱ and plasma VEGF levels after treatment in patients with leu-kemia. Methods Serum IGF-Ⅱ （with RIA） and plasma VEGF （with ELISA） levels were determined in 32 patients with acute leu-kemia both before and after treatment as well as in 35 controls. Results Before treatment, the serum IGF-Ⅱ and plasma VEGF levels in patients were significantly higher than those in controls （P〈0.01）. After 6months of treatment the levels though corrected markedly remained significantly higher than those in controls （P 〈 0.05）. Conclusion The development and clinical course of acute leukemia were closely related to the serum IGF-Ⅱ and plasma VEGF levels.