卵巢癌患者手术治疗前后血清CEA、CA125和IL-8联检的临床意义

Clinical Significance of Combined Determination of Changes of Serum CEA,CA125 and IL-8 Levels After Operation in Patients with Ovarian Cancer

目的:探讨了卵巢癌患者手术治疗前后血清CEA、CA125和IL-8水平的变化及意义。方法:应用放射免疫分析和酶联免疫分析对32例卵巢癌患者进行了手术治疗前后血清CEA、CA125和IL-8检测,并与35名正常健康人作比较。结果:在手术治疗前卵巢癌患者CEA、CA125和IL-8水平非常显著地高于正常人组(P<0.01),经手术治疗6个月后则与正常人比较无显著性差异(P>0.05)。结论:检测血清CEA、CA125和IL-8水平的变化对观察病情和预后判定均具有重要的临床价值。

Objective To explore the changes of serum CEA, CA125 and IL-8 levels both before and after operation in patients with ovarian cancer. Methods Serum CEA, CA125 and IL - 8 （with RIA） and IL - 8 （with ELISA） levels were measured in 32 patients with ovarian cancer both before and after operation as well as in 35 controls. Results Before operation the serum CEA, CA125 and IL-8 levels were significantly higher in the patients than those in the controls （P 〈0.01 ）. Six months after operation the levels were not significantly different from those in controls （P〉0.05）. Conclusion Detection of senma CEA, CA125 and IL - 8 levels after operation might be of prognostic importance in patients with ovarian cancer.